Propyl mercaptan → HCID 67280468, compound

Participants

Reaction Steps

Propanethiol (3.1 ml) was added to a stirred suspension of sodium hydride (1.4 g, 60% in oil) in DMF (30 ml). After 1 hour a solution of the product from step (i) (2.4 g) in DMF (10 ml) was added. The reaction mixture was stirred at RT for 1 hour then partitioned between EtOAc and water. The organics were washed with water, brine, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 5% EtOAc/isohexane. Yield 1.87 g

Provenance & Evidence