HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoamyl Nitrite → 2-Chloro-4-(ethylthio)-1-iodo-benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoamyl Nitrite | HCID 8053 | — |
| Reactant | Diethyl disulfide | HCID 8077 | — |
| Reactant | 3-Chloro-4-iodoaniline | HCID 282926 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 2-Chloro-4-(ethylthio)-1-iodo-benzene | HCID 67280185 | — |
Reaction Steps
A solution of 3-chloro-4-iodo-aniline (5.6 g), isoamylnitrite (8.8 ml) and ethyldisulphide (13.4 ml) in acetonitrile (100 ml) was heated at 60° C. for 24 h. The solvent was removed under reduced pressure and the residue purified by chromatography on silica eluting with 1% ethylacetate/isohexane. Yield 4.02 g
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158820B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-7c48071fe59d41d998676c0323da739d |
| Source note | uspto-grants-2012_04 |