2-Benzyloxy-5-chlorobenzeneboronic acid → 5′-Chloro-4-(ethylsulfonyl)-2-fluoro-2′-(phenylmethoxy)-1,1′-biphenyl

HRID 1694713Notes

Reaction equation

HRID 1694713 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[F:13].[CH2:14]([O:21][C:22]1[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][C:23]=1B(O)O)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[Cl:28][C:25]1[CH:26]=[CH:27][C:22]([O:21][CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[C:23]([C:2]2[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=2[F:13])[CH:24]=1

Participants

3

Reactant 2

HCID 41987402-Benzyloxy-5-chlorobenzeneboronic acidHCID 67280287HCID 67280287, compound

Product 1

HCID 672803325′-Chloro-4-(ethylsulfonyl)-2-fluoro-2′-(phenylmethoxy)-1,1′-biphenyl

Procedure

The subtitle compound was prepared by the method of example 1 step (ii) using the product from step (ii) and the product from example 16 step (ii). Yield 0.55 g

Sources & evidence

ORD record
ord-5fa94c324c6b402e828c5cc5e58db44d
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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