4-Ethylthiophenylboronic acid → 2-[[5-Chloro-4'-(ethylthio)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid, 1,1-dimethylethyl ester

HRID 1694716Notes

Reaction equation

HRID 1694716 reaction equation
Br[C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[O:4][CH:5]([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[CH2:19]([S:21][C:22]1[CH:27]=[CH:26][C:25](B(O)O)=[CH:24][CH:23]=1)[CH3:20]>>[Cl:18][C:16]1[CH:15]=[CH:14][C:3]([O:4][CH:5]([CH3:13])[C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])=[C:2]([C:25]2[CH:26]=[CH:27][C:22]([S:21][CH2:19][CH3:20])=[CH:23][CH:24]=2)[CH:17]=1

Participants

3

Reactant 2

HCID 27343534-Ethylthiophenylboronic acidHCID 663388322-(2-Bromo-4-chlorophenoxy)-propanoic acid, 1,1-dimethylethyl ester

Product 1

HCID 866092182-[[5-Chloro-4'-(ethylthio)[1,1'-biphenyl]-2-yl]oxy]-propanoic acid, 1,1-dimethylethyl ester

Procedure

The subtitle compound was prepared by the method of example 1 step (ii) using the product from step (i) and 4-(ethylthio)benzeneboronic acid, yield 1.2 g.

Sources & evidence

ORD record
ord-131890eda6ae47a8b4f5cdc60705d0cb
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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