2-Benzyloxy-5-trifluoromethylphenylboronic acid → [[[4'-(Ethylsulfonyl)-2'-methyl-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]methyl]-benzene

HRID 1694717Notes

Reaction equation

HRID 1694717 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([CH2:11][CH3:12])(=[O:10])=[O:9])=[CH:4][C:3]=1[CH3:13].[C:14]1([CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=2B(O)O)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH2:11]([S:8]([C:5]1[CH:6]=[CH:7][C:2]([C:23]2[CH:24]=[C:25]([C:28]([F:31])([F:30])[F:29])[CH:26]=[CH:27][C:22]=2[O:21][CH2:20][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)=[C:3]([CH3:13])[CH:4]=1)(=[O:10])=[O:9])[CH3:12]

Participants

3

Reactant 2

HCID 230053392-Benzyloxy-5-trifluoromethylphenylboronic acidHCID 593508341-Bromo-4-(ethylsulfonyl)-2-methylbenzene

Product 1

HCID 67280051[[[4'-(Ethylsulfonyl)-2'-methyl-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]methyl]-benzene

Procedure

The subtitle compound was prepared by the method of example 1 step (ii) using the product from step (i) and (ii), yield 2.72 g.

Sources & evidence

ORD record
ord-36985e70838846e2967ec2ec15d5c3cf
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

Loading…