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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1694744Generated: October 25, 2026

(2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acid → 2-[[2'-Chloro-4'-[(dimethylamino)sulfonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-(2S)-propanoic acid

https://huagongshe.com/reaction/1694744

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S)-2-[2-borono-4-(trifluoromethyl)phenoxy]-propanoic acidHCID 67277101—
Reactant3-Chloro-4-iodo-N,N-dimethylbenzenesulfonamideHCID 67280204—
Product2-[[2'-Chloro-4'-[(dimethylamino)sulfonyl]-5-(trifluoromethyl)[1,1'-biphenyl]-2-yl]oxy]-(2S)-propanoic acidHCID 11476492—

Reaction Steps

The title compound was prepared by the method of example 144 step (i) using the product from step (ii) and the product from example 146 step (iv).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08158820B2
Source datasetuspto-grants-2012_04
ORD IDord-9dd2adb4d5c140d6955b8e9b625e2da3
Source noteuspto-grants-2012_04