2-Benzyloxy-5-chlorobenzeneboronic acid → [[[2',5-Dichloro-4'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]oxy]methyl]benzene

HRID 1694746Notes

Reaction equation

HRID 1694746 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:10]=1B(O)O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Cl:19][C:20]1[CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[CH:22][C:21]=1I>>[Cl:19][C:20]1[CH:25]=[C:24]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:23]=[CH:22][C:21]=1[C:10]1[CH:11]=[C:12]([Cl:15])[CH:13]=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 41987402-Benzyloxy-5-chlorobenzeneboronic acidHCID 593508192-Chloro-1-iodo-4-(methylsulfonyl)benzene

Product 1

HCID 86006154[[[2',5-Dichloro-4'-(methylsulfonyl)[1,1'-biphenyl]-2-yl]oxy]methyl]benzene

Procedure

The subtitle compound was prepared by the method of example 144 step (i) using the product from example 16 step (ii) and the product from example 145 step (ii). Yield 1.08 g.

Sources & evidence

ORD record
ord-ed8d887a6e95473289352051e637e323
Source dataset
uspto-grants-2012_04
Patent number
US08158820B2

Reaction notes

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