Dimethyl Sulfide → 4-Bromo-1-(methylthio)-2-(trifluoromethyl)-benzene

Participants

Reaction Steps

Isopentyl nitrite (0.67 ml) was added dropwise to a solution of 4-bromo-2-(trifluoromethyl)aniline (1.2 g) and dimethyl sulfide (0.45 ml) in acetonitrile (12 ml). The reaction was slowly heated to reflux and then refluxed until gas evolution ceased. The volatiles were evaporated, the residue absorbed onto silica and the product eluted off with isohexane. Yield 0.8 g.

Provenance & Evidence