HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(5-bromo-4-methylpyridin-2-yl)methanesulfonamide | HCID 67280818 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamide | HCID 67280607 | — |
Reaction Steps
The product from step (i) (2.23 g), potassium carbonate (2.33 g) and methyl iodide (0.7 ml) were stirred in DMF (20 ml) for 20 h. The reaction was quenched with water, extracted with EtOAc, dried (MgSO4) and evaporated. The residue was purified by chromatography on silica eluting with 30% EtOAc/isohexane. Yield 1.5 g. Carried forward to step (ii) without characterisation.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158820B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-162851ddd35c48c4be538806b1fc5bdf |
| Source note | uspto-grants-2012_04 |