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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1694763Generated: October 25, 2026

(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid → 2-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2s)-propanoic acid

https://huagongshe.com/reaction/1694763

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67277298—
ReactantN-(5-Bromo-4-methyl-2-pyridinyl)-N-methylmethanesulfonamideHCID 67280607—
Product2-[4-Chloro-2-[4-methyl-6-[methyl(methylsulfonyl)amino]-3-pyridinyl]phenoxy]-(2s)-propanoic acidHCID 58333651—

Reaction Steps

The title compound was prepared by the method of example 155 using the product from step (ii) and the product from example 151 step (iv). Yield 0.125 g.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08158820B2
Source datasetuspto-grants-2012_04
ORD IDord-28c6aaf17ecc4e7ead3f0558f57bb518
Source noteuspto-grants-2012_04