HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 20083278, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | Butylamine | HCID 8007 | — |
| Reactant | 2,6-Difluoro-4-methoxybenzaldehyde | HCID 3703713 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Catalyst | Manganese(2+) dichloride | HCID 10313134 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 20083278 | HCID 20083278 | — |
Reaction Steps
Prepared in analogy to Example 57(a)-(b) from 2,6-difluoro-4-methoxybenzaldehyde, N-butylamine and p-toluenesulphonic acid in toluene, then treatment with 3 equivalents of ethylmagnesium bromide and manganese(II) chloride in tetrahydrofuran and ether followed by chromatography on silical gel. MS (ISP): 193.3 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08158668B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-fb16f8ee2e4e489ebae47c2d9d52f00a |
| Source note | uspto-grants-2012_04 |