Trifluoroacetic acid → HCID 44442354, compound

Participants

Reaction Steps

To a solution of tert-butyl [2-({4-[2-anilino-1-(anilinocarbonyl)-1-fluoro-2-oxoethyl]benzoyl}amino)phenyl]carbamate (11 mg, 0.019 mmol) in CH2Cl2 (3 mL) at room temperature was added trifluoroacetic acid (1 mL). The reaction mixture was stirred at room temperature 45 min and concentrated. Purification by reverse phase HPLC (10% to 80% MeCN in water) gave 2-(4-{[(2-aminophenyl)amino]carbonyl}phenyl)-2-fluoro-N,N′-diphenylmalonamide (2.1 mg, TFA salt, 19%) as a white solid: 1H NMR (600 MHz, CD3OD) δ 8.13 (d, J=8.2 Hz, 2H), 7.95 (d, J=8.5 Hz, 2H), 7.64-7.62 (m, 4H), 7.41-7.35 (m, 8H), 7.18 (t, J=7.6 Hz, 2H); ESIMS calcd 483.2 (M++H), found 483.1 (M++H). General Procedure for the Synthesis of Non-Symmetrical Malonamide Benzamides

Provenance & Evidence