Dimethyl malonate → N,N'-bis(4-fluorophenyl)propanediamide

Participants

Reaction Conditions

Reaction Steps

A mixture of dimethyl malonate (0.5 g, 3.78 mmol) and 4-fluoroaniline (0.93 g, 8.33 mmol) was heated neat to 200° C. for 20 min in the microwave system. After cooling, the solid was filtered and washed with ethyl acetate to provide the desired malonamide which was used without further purification. MS: Cal'd (MH+) 291, exp (MH+) 291.

Provenance & Evidence