Hexane → {(1S,2S,4S)-1-[4-(2-Chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-ylmethyl]-2-hydroxy-5-methyl-4-(2,2,2-trifluoroethyl)carbamoylhexyl}carbamic acid t-butyl ester

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Reaction Steps

2 ml of a solution of dimethylaluminum chloride in n-hexane (1.0 mol/l) (2 mmol) was added to a solution of 160 μl of (2,2,2-trifluoroethyl)amine (2 mmol) in methylene chloride under a nitrogen atmosphere at room temperature, and the mixture was stirred at room temperature for one hour. A solution of 200 mg of {(S)-2-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-1-[(2S,4S)-4-isopropyl-5-oxotetrahydrofuran-2-yl]ethyl}carbamic acid t-butyl ester obtained in Example (1m) (0.39 mmol) in methylene chloride (4 ml) was added to the solution obtained above, and the mixture was stirred at room temperature for 26 hours. A 10% potassium sodium tartrate aqueous solution was added to the reaction mixture, followed by dilution with ethyl acetate. Then, the mixture was stirred at room temperature for 0.5 hour. The reaction mixture was extracted with ethyl acetate, and then the organic layer was washed with brine and dried over anhydrous magnesium sulfate. After filtration, the solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (elution solvent:methylene chloride/methanol=40/1) to obtain 132 mg of the title compound (yield: 55%).

Provenance & Evidence