反应详情

N-(2-Amino-4-fluorophenyl)-6-chloronicotinamide (266 mg, 1 mmol) and 7 ml of 1,4-butanediamine were heated to 80° C. for 3 hours. The excess 1,4-butanediamine was removed under vacuum. To the residue was added 5 ml of 0.20 M NaOH. The mixture was extracted with 100 ml of ethyl acetate. The ethyl acetate was removed under vacuum to give the title compound (149 mg, 47% yield) as a brown solid. LC-MS (m/z) 318 (M+1).

1. customThe excess 1,4-butanediamine was removed under vacuum
2. additionTo the residue was added 5 ml of 0.20 M NaOH
3. extractionThe mixture was extracted with 100 ml of ethyl acetate
4. customThe ethyl acetate was removed under vacuum