HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylphosphine → HCID 86615610, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylphosphine | HCID 68983 | — |
| Reactant | N-[4-(2-Amino-9-(3-azidopropyl)-purine-6-yloxymethyl)-benzyl]-2,2,2-trifluoro-acetamide | HCID 58989129 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | HCID 86615610 | HCID 86615610 | — |
Reaction Steps
Azide 23 (Example 10, 100 mg, 0.23 mmol) is dissolved in 0.9 mL of 1,4-dioxane/H2O (8:1), and 0.3 mL of a trimethylphospine solution (1 M in THF) is added. The reaction is stirred at room temperature for 3 h, then all volatiles are removed in vacuo. The crude product is purified by flash column chromatography with dichloromethane/methanol (95:5 to 10:1). Yield: 87 mg (0.021 mmol, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163479B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-089f68b08fe543bfbdedd8c9521524ae |
| Source note | uspto-grants-2012_04 |