化工社化工社 化学情報印刷レポート · 研究参考用
Methanol → (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Thionyl Chloride | HCID 24386 | — |
| 反応物 | (2R,4S)-4-hydroxypyrrolidine-2-carboxylic acid | HCID 440074 | — |
| 生成物 | (2R,4S)-methyl 4-hydroxypyrrolidine-2-carboxylate | HCID 7021430 | — |
反応手順
Thionyl chloride (0.83 ml, 11.4 mmol) is added dropwise into a suspension of H-D-Hyp-OH (1.0 g, 7.6 mmol) in methanol (25 ml) at 0° C. The mix is stirred at room temperature for 1 hr, then 65° C. for another 1 hr. Solvent is evaporated to dryness. Compound 18 is obtained as a white crystal and used for the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08163693B2 |
| 出典データセット | uspto-grants-2012_04 |
| ORD ID | ord-f505b88a3c2b4336a8c232e04437f6e4 |
| 出典メモ | uspto-grants-2012_04 |