1,2,3,4-Tetrahydroisoquinoline → HCID 67276693, compound

Participants

Reaction Steps

Compound 19 (1.28 g, 4.6 mmol) dissolved in DCM (20 ml) is added dropwise into CDI (0.75 g, 4.6 mmol) solution in DCM (30 ml). After stirring for 2 hr, 1,2,3,4-tetrahydroisoquinoline (0.644 ml, 4.6 mmol) is added and the mixture is stirred over night. The solvent is removed and residue applied to flash chromatography on silica gel (Hex/ethyl acetate, 2/1 to 1/1). Compound 20 (1.8 g, 90%) is obtained as pale yellow syrup.

Provenance & Evidence