Water → 4-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-morpholine

HRID 1695130Notes

Reaction equation

HRID 1695130 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[Br:7][C:8]1[CH:13]=[CH:12][C:11]([S:14](Cl)(=[O:16])=[O:15])=[C:10]([C:18]([F:21])([F:20])[F:19])[CH:9]=1.O>C(Cl)Cl>[Br:7][C:8]1[CH:13]=[CH:12][C:11]([S:14]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:15])=[O:16])=[C:10]([C:18]([F:21])([F:19])[F:20])[CH:9]=1

Participants

5

Reactant 3

HCID 962WaterHCID 8083MorpholineHCID 27786084-Bromo-2-(trifluoromethyl)benzenesulfonyl chloride

Product 1

HCID 473151804-(4-Bromo-2-trifluoromethyl-benzenesulfonyl)-morpholine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
20 °C

Procedure

Morpholine (1.1 ml) was added to a solution of [4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride (2.03 g) in DCM (7 ml) at 0° C. and stirred at 20° C. for 16 h. Water was added and the mixture was extracted with DCM. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol—ether as to eluent) to give the sub-title compound 2.10 g).

Workup

  1. extractionthe mixture was extracted with DCM
  2. dry with materialThe organic extracts were dried (MgSO4)
  3. customevaporated
  4. custompurified by chromatography (silica, petrol—ether as to eluent)

Sources & evidence

ORD record
ord-7016b7610b0349f7b2c7f1ed1b0c073d
Source dataset
uspto-grants-2012_04
Patent number
US08163727B2

Reaction notes

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