HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 11582566, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 4-bromo-2-fluoro-N,N-bis(1-methylethyl)-benzamide | HCID 67277185 | — |
| Reactant | (2S)-2-(2-borono-4-chlorophenoxy)-propanoic acid | HCID 67277298 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 11582566 | HCID 11582566 | — |
Reaction Steps
The product of step c) (200 mg), the product of step d) (200 mg), Pd(dppf)Cl2 (60 mg), sodium carbonate (350 mg) and dioxan (5 ml) were charged to a flask and heated at reflux for 24 h, then cooled to room temp and filtered (hyflo). The filtrate was concentrated in vacuo, then purified by reverse phase HPLC to give the title compound. Yield 22 mg
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163727B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a77131466983404fbd23f6108926506d |
| Source note | uspto-grants-2012_04 |