N-Methylisopropylamine → 4-bromo-2-fluoro-N-methyl-N-(1-methylethyl)-benzamide

HRID 1695148Notes

Reaction equation

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH3:12][NH:13][CH:14]([CH3:16])[CH3:15]>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:13]([CH3:12])[CH:14]([CH3:16])[CH3:15])=[O:8])=[C:4]([F:11])[CH:3]=1

Participants

Reactant 2

HCID 78485N-Methylisopropylamine

HCID 3026814-Bromo-2-fluorobenzoic acid

Product 1

HCID 247056274-bromo-2-fluoro-N-methyl-N-(1-methylethyl)-benzamide

Procedure

The sub-title compound was prepared by the method of example 18 step a) using 4-bromo-2-fluorobenzoic acid and N-methyl-2-propanamine.

Sources & evidence

ORD record: ord-77ca9a889302412a83c8fd85dee0e80c
Source dataset: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08163727B2

Reaction notes

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