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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695156Generated: October 25, 2026

(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acid → (2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acid

https://huagongshe.com/reaction/1695156

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(2S)-2-[[4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro-5-(trifluoromethyl) [1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 11539174—
Reactant(2S)-2-(2-borono-4-chlorophenoxy)-propanoic acidHCID 67277298—
Product(2S)-2-[[5-chloro-4'-[[(1,1-dimethylethyl)amino]carbonyl]-3'-fluoro[1,1'-biphenyl]-2-yl]oxy]-propanoic acidHCID 11538441—

Reaction Steps

The title compound was prepared using the product of example 33 step a) and the product of example 28 step c) by the method of example 32 step b).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08163727B2
Source datasetuspto-grants-2012_04
ORD IDord-8bd2a9ec66754e9b99909a43a39f7273
Source noteuspto-grants-2012_04