Bis(tributyltin) oxide → HCID 86645806, compound

Participants

Reaction Steps

The (2R,3S)-3-benzoyloxy-2-pentylnonanoic acid t-butyl ester (1.24 g, 3.06 mmol) obtained in Production Example C-7-1 was dissolved in anhydrous toluene (4 ml), and then tributyltin oxide (2.34 g, 3.92 mmol) was added thereto to be refluxed with heating. Then, 39 hours later, distilled water was added to the reaction mixture, and extracted 3 times with diethyl ether. The resulting organic layer was dried with anhydrous magnesium sulfate, filtered, and condensed. The obtained residue was purified by column chromatography (silica gel: 30 g, n-hexane/ethyl acetate=20/1), and the target compound (501 mg, 54%) was obtained.

Provenance & Evidence