HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-Chloro-4-fluorobenzoate → 2-Chloro-4-fluoro-β-oxobenzenepropanenitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-Chloro-4-fluorobenzoate | HCID 2763551 | — |
| Reactant | HCID 178418806 | HCID 178418806 | — |
| Product | 2-Chloro-4-fluoro-β-oxobenzenepropanenitrile | HCID 24691631 | 60% |
Reaction Steps
The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 2-chloro-4-fluoro-benzoic acid methyl ester (0.7 g, 3.7 mmol, 1.0 eq). The crude product was extracted with DCM and used in the following step without further purification (0.4 g, yield: 60%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163729B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-35497e4c044a4424b7ba33b570138664 |
| Source note | uspto-grants-2012_04 |