HCID 603339, compound → HCID 3610447, compound

HRID 1695176Notes

Reaction equation

HRID 1695176 reaction equation
[NH2:1][C:2]1[CH:6]=CNN=1.CO[C:9]([C:11]1[S:12][C:13]([C:16]([CH3:19])([CH3:18])[CH3:17])=[CH:14][CH:15]=1)=[O:10]>>[C:16]([C:13]1[S:12][C:11]([C:9](=[O:10])[CH2:6][C:2]#[N:1])=[CH:15][CH:14]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 603339HCID 603339, compoundHCID 178418806HCID 178418806, compound

Product 1

HCID 3610447HCID 3610447, compoundYield 86%

Procedure

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 5-tert-Butyl-thiophene-2-carboxylic acid methyl ester (3.0 g, 15.0 mmol, 1.0 eq). The crude product was extracted with DCM and used in the following step without further purification (2.7 g, yield: 86%).

Workup

  1. customThe product was prepared
  2. extractionThe crude product was extracted with DCM
  3. customused in the following step without further purification (2.7 g, yield: 86%)

Sources & evidence

ORD record
ord-d45ce1eeb2514da6a16a9f98a6a9eea2
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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