Methyl 3-chloro-2-methylbenzoate → HCID 23468535, compound

HRID 1695178Notes

Reaction equation

HRID 1695178 reaction equation
[NH2:1][C:2]1[CH:6]=CNN=1.CO[C:9](=[O:18])[C:10]1[CH:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:11]=1[CH3:17]>>[Cl:16][C:12]1[C:11]([CH3:17])=[C:10]([C:9](=[O:18])[CH2:6][C:2]#[N:1])[CH:15]=[CH:14][CH:13]=1

Participants

3

Reactant 2

HCID 5077673Methyl 3-chloro-2-methylbenzoateHCID 178418806HCID 178418806, compound

Product 1

HCID 23468535HCID 23468535, compoundYield 74%

Procedure

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1) from 3-Chloro-2-methyl-benzoic acid methyl ester (3.1 g, 16.8 mmol, 1.0 eq). The crude product was precipitated form water and used in the following step without further purification (2.4 g, yield: 74%).

Workup

  1. customThe product was prepared
  2. customThe crude product was precipitated form water
  3. customused in the following step without further purification (2.4 g, yield: 74%)

Sources & evidence

ORD record
ord-f7e54ffe8c33450aae90cbcef6be8f46
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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