Methanol → HCID 22999141, compound

HRID 1695188Notes

Reaction equation

HRID 1695188 reaction equation
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([F:11])[C:3]=1[F:12].S(=O)(=O)(O)O.[CH3:18]O>>[CH3:18][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[C:3]([F:12])[C:4]=1[F:11]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 27793072,3-difluoro-4-hydroxybenzoic acid

Product 1

HCID 22999141HCID 22999141, compound

Procedure

4-hydroxy-2,3-difluoro-benzoic acid (2.0 g, 11.5 mmol) was dissolved in MeOH (20 mL) and catalytic quantity of sulfuric acid was added. The mixture was refluxed overnight, after that the solvent was evaporated under reduced pressure; the crude was dissolved in DCM and washed with saturated NaHCO3. The organic phase was dried and evaporated under reduced pressure, and the product was used without further purification.

Workup

  1. temperatureThe mixture was refluxed overnight
  2. customafter that the solvent was evaporated under reduced pressure
  3. dissolutionthe crude was dissolved in DCM
  4. washwashed with saturated NaHCO3
  5. customThe organic phase was dried
  6. customevaporated under reduced pressure
  7. customthe product was used without further purification

Sources & evidence

ORD record
ord-37ba5c0430724ddc9640e17cb6d1f7a0
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

Loading…