N-[4-(4-Trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-acetamide → 4-(4-Trifluoromethoxy-phenyl)-1H-imidazol-2-ylamine

Participants

Reaction Steps

N-[4-(4-Trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-acetamide (0.7 g, 2.6 mmol, 1.0 eq) was dissolved in water (18 mL) and methanol (18 mL), and 20 drops of sulfuric acid were added. The reaction was refluxed for 2 days, then the mixture was dried; the residue was diluted with water, the pH adjusted to 8 with NaOH 2N, the product was extracted with DCM and concentrated under reduced pressure to give 0.6 g of the title compound (yield 98%)

Provenance & Evidence