反应详情

温度

80 °C

To a solution of 6-methoxy-naphthalene-2-carboxylic acid (1.01 g, 5 mmol) in methanol (10 mL), a catalytic amount of sulphuric acid was added. The mixture was then heated at 80° C. for 8 hours. Upon reaction completion (as monitored by LcMS), the solution was slowly cooled and the precipitation of the product was observed. Filtration of the white solid afforded 1.01 g (94% yield) of title compound

1. customUpon reaction completion (as monitored by LcMS)
2. temperaturethe solution was slowly cooled
3. customthe precipitation of the product
4. filtrationFiltration of the white solid