HCID 67188192, compound → HCID 178461414, compound

HRID 1695229Notes

Reaction equation

HRID 1695229 reaction equation
[F:1][CH:2]([F:16])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:11]=[C:12]([NH2:15])[NH:13][N:14]=2)=[CH:6][CH:5]=1.[CH3:17][C@H:18]1[CH2:22][CH2:21][CH2:20][N:19]1[CH2:23][CH2:24][CH2:25][C:26](O)=[O:27]>>[F:16][CH:2]([F:1])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:11]=[C:12]([NH:15][C:26](=[O:27])[CH2:25][CH2:24][CH2:23][N:19]3[CH2:20][CH2:21][CH2:22][C@@H:18]3[CH3:17])[NH:13][N:14]=2)=[CH:8][CH:9]=1

Participants

3

Reactant 2

HCID 67188192HCID 67188192, compoundHCID 178507295HCID 178507295, compound

Product 1

HCID 178461414HCID 178461414, compound

Procedure

Prepared following the general synthetic method for the one-pot synthesis of ω-amino-alkanoic acid (1H-pyrazol-3-yl-5-aryl)-amides, starting from 5-(4-Difluoromethoxy-phenyl)-2H-pyrazol-3-ylamine (112.5 mg, 0.5 mmol, 1.0 eq) and 4-((S)-2-Methyl-pyrrolidin-1-yl)-butyric acid (155.0 mg, 0.8 mmol, 1.5 eq).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-4e0a2380a4ba4895878eb66d45c462f5
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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