4-(1-Methylethoxy)-beta-oxobenzenepropanenitrile → 3-[4-(propan-2-yloxy)phenyl]-1H-pyrazol-5-amine

Participants

Reaction Steps

The product was prepared from 3-(4-isopropoxy-phenyl)-3-oxo-propionitrile according to general procedure for aminopyrazole synthesis (route A2). The solvent was removed under reduced pressure, water (10 mL) was added, and the title product (1.0 g, 94% yield) was precipitated as a yellow solid and used for the next step without further purification.

Provenance & Evidence