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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1695237Generated: October 30, 2026

Methyl 1-ethylindole-3-carboxylate → 3-(1-Ethyl-1H-indol-3-yl)-3-oxo-propionitrile

https://huagongshe.com/reaction/1695237

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl 1-ethylindole-3-carboxylateHCID 5191495—
ReactantHCID 178418806HCID 178418806—
Product3-(1-Ethyl-1H-indol-3-yl)-3-oxo-propionitrileHCID 6718802591%

Reaction Steps

The product was prepared according to the general procedure for aminopyrazole synthesis (route A1bis) from 1-ethyl-1H-indole-3-carboxylic acid methyl ester (860.0 mg, 4.2 mmol, 1.0 eq). 820.0 mg of the title product (yield 91%) were obtained and used directly for the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08163729B2
Source datasetuspto-grants-2012_04
ORD IDord-fb38623cd966453292ae4a72f843fb58
Source noteuspto-grants-2012_04