Formate → HCID 178462496, compound

HRID 1695239Notes

Reaction equation

HRID 1695239 reaction equation
[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:13]=[C:14]([NH2:17])[NH:15][N:16]=2)=[CH:4]1)[CH3:2].[N:18]1([CH2:23][CH2:24][CH2:25][C:26](O)=[O:27])[CH2:22][CH2:21][CH2:20][CH2:19]1.C([O-])=O>>[CH2:1]([N:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([C:12]2[CH:13]=[C:14]([NH:17][C:26](=[O:27])[CH2:25][CH2:24][CH2:23][N:18]3[CH2:22][CH2:21][CH2:20][CH2:19]3)[NH:15][N:16]=2)=[CH:4]1)[CH3:2]

Participants

4

Reactant 3

HCID 283FormateHCID 148556811-Pyrrolidinebutanoic acidHCID 178462497HCID 178462497, compound

Product 1

HCID 178462496HCID 178462496, compoundYield 42.1%

Procedure

The product was prepared according to the general synthetic method for the synthesis of ω-amino-alkanoic acid (1H-pyrazol-3-yl-5-aryl)-amides via the amino acid route, starting from 5-(1-ethyl-1H-indol-3-yl)-2H-pyrazol-3-ylamine (99.0 mg, 0.5 mmol, 1.0 eq) and 4-pyrrolidin-1-yl-butyric acid (118 mg, 0.75 mmol). The crude product was purified via preparative HPLC; the title product (77.0 mg, 42% yield) was obtained as formate salt.

Workup

  1. customThe product was prepared
  2. customThe crude product was purified via preparative HPLC

Sources & evidence

ORD record
ord-e97dce1c27f3412ea599d8081d8e3495
Source dataset
uspto-grants-2012_04
Patent number
US08163729B2

Reaction notes

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