Hydrochloric Acid → HCID 178488666, compound

Participants

Reaction Steps

5-[5-(4-Acetyl-[1,4]diazepan-1-yl)-2-methyl-pentanoylamino]-3-(4-methoxy-phenyl)-pyrazole-1-carboxylic acid tert-butyl ester (181.0 mg, 0.34 mmol, 1.0 eq) was dissolved in DCM (3 mL) and HCl 4.0 M in dioxane (0.16 mL, 0.64 mmol, 1.9 eq) was added at room temperature. After 3 hours another 1.9 eq of HCl was added and the mixture stirred for 3 additional hours. NaHCO3 saturated solution was added and the organic layer collected and dried. Evaporation of solvent gave the title product (120 mg; Yield 82%).

Provenance & Evidence