Pyridine → HCID 11569825, compound

Participants

Reaction Conditions

Reaction Steps

Mesyl chloride (0.16 mL, 2.059 mmol) was added to a solution of 4-Chloro-6-methyl-10,10-dioxo-2-piperazin-1-yl-10,11-dihydro-5-oxa-10lambda*6*-thia-dibenzo[a,d]cycloheptene-8-carboxylic acid methyl ester (free base of example 16, 0.3 g, 0.687 mmol) in dichloromethane (20 mL) and stirred at 20° C. for 10 min. To this pyridine (0.3 mL, 4.12 mmol) was added and the reaction mixture was stirred further for 5 h. The reaction mixture was washed using aqueous hydrochloric acid 10% (15 mL), water and then brine solution. Solvent was removed and the crude product obtained was purified by column chromatography (silica gel, 1% methanol in chloroform) to obtain the title compound. Yield: 0.14 g, (38.45%); 1H NMR (DMSO-d6, 300 MHz): δ 2.63 (s, 3H, CH3), 2.90 (s, 3H, CH3), 3.22 (s, 4H, 2CH2); 3.31 (s, 4H, CH2); 3.85 (s, 3H, OCH3); 5.16 (s, 2H, CH2), 7.13 (d, 1H, Ar), 7.18 (s, 1H, Ar), 8.09 (t, 1H, Ar), 8.15 (d, 1H, Ar); MS: m/e (ES+) 515 (M+1); analysis: C21 H23ClN2O7S2.H2O requires C, 47.32,H, 4.73, N, 5.26, Cl, 6.65, S, 12.03; found: C, 46.86, H, 4.18, N, 4.96, Cl, 7.11, S, 12.57%.

Provenance & Evidence