1,1'-Carbonyldiimidazole → HCID 11591381, compound

Participants

Reaction Steps

1,1′-Carbonyldiimidazole (0.172 g, 11 mmol) was added at 25° C., to a stirred solution of compound of Example 18 (0.3 g, 7 mmol) in dry DMF (10 mL) under nitrogen atmosphere. The reaction mixture was stirred for 2 h, and cyclopropyl amine (0.06 mL, 8.4 mmol) was added. The reaction mixture was stirred at 25° C. for 2 h. Solvent was partially removed and the reaction mixture was diluted with water (50 mL), The solid separated was filtered, washed with water and dried. The product was converted to its hydrochloride salt using methanolic-HCl to obtain the title compound. Yield: 0.15 g (42.5%); 1H NMR (DMSO-d6, 300 MHz): δ 0.56 (s, 2H, CH2), 0.66 (d, 2H, CH2), 2.61 (s, 3H, CH3), 2.82 (bs, 1H, CH), 3.20-3.36 (m, 8H, 4CH2), 5.11 (s, 2H, CH2), 7.14 (d, 1H, Ar), 7.66 (d, 1H, Ar), 8.01 (s, 1H, Ar), 8.13 (s, 1H, Ar), 8.67 (s, 1H, NH); MS: m/e (ES+) 462 (M+1, freebase).

Provenance & Evidence