Oxolan-3-amine → Rac-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2h-pyrazole-3-carboxylic acid (tetra-hydro-furan-3-yl)-amide

Participants

Reaction Steps

As described for example 1b, 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.32 mmol) was converted, using rac-3-aminotetrahydrofuran instead of morpholine, to the title compound (39 mg, 33%), which was obtained as a white solid. MS: m/e=369.2 [M+H]+.

Provenance & Evidence