反应详情

温度

90 °C

To a solution of 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.32 mmol) and ethanolamine (29 mg, 0.47 mmol) in toluene (1 mL) was added 1,5,7-triazabicyclo[4.4.0]dec-5-ene (16 mg, 0.11 mmol) and the reaction was heated at 90° C. under argon overnight. After cooling to room temperature, the mixture was evaporated and purification by chromatography (silica, dichloromethane:methanol=100:0 to 9:1) afforded the title compound (30 mg, 28%), which was obtained as a white solid. MS: m/e=343.2 [M+H]+.

1. temperatureAfter cooling to room temperature
2. customthe mixture was evaporated
3. custompurification by chromatography (silica, dichloromethane:methanol=100:0 to 9:1)