1,1-Dimethylhydrazine → 5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide

Participants

Reaction Steps

As described for example 8b, 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.3 mmol) was converted, using N,N-dimethylhydrazine instead of 4-aminomorpholine, to the title compound (25 mg, 23%), which was obtained as a white solid after recrystallization from ethyl acetate. MS: m/e=360.2 [M+H]+.

Provenance & Evidence