Ethanamine, 2,2,2-trifluoro- → 5-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid (2,2,2-trifluoro-ethyl)-amide

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Reaction Steps

As described for example 1b, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.3 mmol), instead of 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester, was converted, using 2,2,2-trifluoroethylamine instead of morpholine, to the title compound (25 mg, 21%), which was obtained as a white solid. MS: m/e=400.0 [M+H]+.

Provenance & Evidence