Oxolan-3-amine → Rac-5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2h-pyrazole-3-carboxylic acid (tetrahydro-furan-3-yl)-amide

Participants

Reaction Steps

As described for example 17e, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.3 mmol) was converted, using rac-3-aminotetrahydrofuran instead of 2,2,2-trifluoroethylamine, to the title compound (46 mg, 40%) which was obtained as a white solid. MS: m/e=388.2 [M+H]+.

Provenance & Evidence