HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylhydrazine → 5-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylhydrazine | HCID 5976 | — |
| Reactant | 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester | HCID 66643803 | — |
| Product | 5-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide | HCID 49792894 | 60% |
Reaction Steps
As described for example 17e, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.3 mmol) was converted, using N,N-dimethylhydrazine instead of 2,2,2-trifluoroethylamine, to the title compound (65 mg, 60%) which was obtained as a white solid. MS: m/e=361.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6967b8bf1eeb442081223299efb8459e |
| Source note | uspto-grants-2012_04 |