HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Aminomorpholine → 5-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid morpholin-4-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Aminomorpholine | HCID 20315 | — |
| Reactant | 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester | HCID 66643803 | — |
| Product | 5-[3-(5-Fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid morpholin-4-ylamide | HCID 49792893 | 94% |
Reaction Steps
As described for example 17e, 5-[3-(5-fluoro-pyridin-2-yl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid methyl ester (50 mg, 0.15 mmol) was converted, using 4-aminomorpholine instead of 2,2,2-trifluoroethylamine, to the title compound (57 mg, 94%) which was obtained as a colorless oil. MS: m/e=403.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-a7f2e0e667a64a4da7098723de8e6df1 |
| Source note | uspto-grants-2012_04 |