HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxolan-3-amine → Rac-5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2h-pyrazole-3-carboxylic acid (tetrahydrofuran-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxolan-3-amine | HCID 3365553 | — |
| Reactant | HCID 66643879 | HCID 66643879 | — |
| Product | Rac-5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2h-pyrazole-3-carboxylic acid (tetrahydrofuran-3-yl)-amide | HCID 59568399 | 48% |
Reaction Steps
As described for example 26d, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (492 mg, 1.7 mmol) was converted, using rac-3-aminotetrahydrofuran instead of 4-aminotetrahydropyran, to the title compound (280 mg, 48%) which was obtained as a colorless oil. MS: m/e=349.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-7dbac6df87774d9897911387db49d93a |
| Source note | uspto-grants-2012_04 |