HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-(-)-2-Amino-1-propanol → 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid ((R)-2-hydroxy-1-methyl-ethyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-(-)-2-Amino-1-propanol | HCID 80308 | — |
| Reactant | HCID 66643879 | HCID 66643879 | — |
| Product | 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid ((R)-2-hydroxy-1-methyl-ethyl)-amide | HCID 66643833 | 90% |
Reaction Steps
As described for example 27, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (100 mg, 0.34 mmol) was converted, using D-alaninol instead of L-alaninol, to the title compound (103 mg, 90%) which was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-5a831134f0f5446492a54ed8f76eccc2 |
| Source note | uspto-grants-2012_04 |