HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid → 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid pyrrolidin-1-ylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid | HCID 66643679 | — |
| Reactant | 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid | HCID 66643819 | — |
| Product | 5-(3-Butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid pyrrolidin-1-ylamide | HCID 59568453 | 48% |
Reaction Steps
As described for example 10b, 5-(3-butyl-5-methyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid (140 mg, 0.5 mmol), instead of 5-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-2H-pyrazole-3-carboxylic acid, was converted, to the title compound (83 mg, 48%), which was obtained as a white solid. MS: m/e=348.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-e1625ccd78ef4eebbd3c5a3b70db7d87 |
| Source note | uspto-grants-2012_04 |