HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxolan-3-amine → Rac-2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2h-pyrazole-3-carboxylic acid (tetrahydro-furan-3-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxolan-3-amine | HCID 3365553 | — |
| Reactant | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester | HCID 66643802 | — |
| Reactant | HCID 66643884 | HCID 66643884 | — |
| Product | Rac-2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2h-pyrazole-3-carboxylic acid (tetrahydro-furan-3-yl)-amide | HCID 49792992 | 80% |
Reaction Steps
As described for example 1b, 2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (30 mg, 0.09 mmol), instead of 5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester, was converted, using rac-3-aminotetrahydrofuran instead of morpholine, to the title compound (28 mg, 80%) which was obtained as a colorless oil. MS: m/e=383.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-2baf82d3fe404d13a966706c0bc1cacd |
| Source note | uspto-grants-2012_04 |