HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester | HCID 66643802 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid amide | HCID 49792991 | 20% |
Reaction Steps
As described for example 42e, 2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (170 mg, 0.52 mmol) was converted, using ammonia in methanol instead of ethanolamine, to the title compound (32 mg, 20%) which was obtained as a white solid. MS: m/e=313.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-65f19af08f0742bdb27405cf27ddd1a3 |
| Source note | uspto-grants-2012_04 |