HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid isopropylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester | HCID 66643802 | — |
| Product | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid isopropylamide | HCID 49792959 | 35% |
Reaction Steps
As described for example 42e, 2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (150 mg, 0.46 mmol) was converted, using isopropylamine instead of ethanolamine, to the title compound (57 mg, 35%) which was obtained as a colorless oil. MS: m/e=355.3 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-9d2f9eb20df34df2ada31e73c3b4710b |
| Source note | uspto-grants-2012_04 |