HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,1-Dimethylhydrazine → 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,1-Dimethylhydrazine | HCID 5976 | — |
| Reactant | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester | HCID 66643802 | — |
| Product | 2-Methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid N',N'-dimethyl-hydrazide | HCID 59568391 | 100% |
Reaction Steps
As described for example 43, 2-methyl-5-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-2H-pyrazole-3-carboxylic acid methyl ester (120 mg, 0.37 mmol) was converted using N,N-dimethylhydrazine instead of rac-3-aminotetrahydrofuran, to the title compound (130 mg, 100%) which was obtained as a colorless oil. MS: m/e=356.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08163728B2 |
| Source dataset | uspto-grants-2012_04 |
| ORD ID | ord-6ec3ce1914cb4bb8b52066a7d10a30e0 |
| Source note | uspto-grants-2012_04 |